| Chemical Properties | Back Directory | [Boiling point ]
746.0±60.0 °C(predicted) | [density ]
1.318±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
14.18±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
PD-L1/PD-1-IN-1 (compound 8j) is a potent inhibitor of PD-L1/PD interaction, with IC50 ＜ 1 nM. PD-L1/PD-1-IN-1 plays an important role in anti-tumor research[1]. | [References]
[1] Damian Muszak, et al. Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction. J Med Chem. 2021 Aug 12;64(15):11614-11636. DOI:10.1021/acs.jmedchem.1c00957 |
|
|