| Identification | Back Directory | [Name]
2-Butenamide, 4-(6,7-dimethoxy-1-oxo-2(1H)-isoquinolinyl)-N-(3-methylbutyl)-, (2E)- | [CAS]
2755772-63-3 | [Synonyms]
Immunoproteasome inhibitor 1
2-Butenamide, 4-(6,7-dimethoxy-1-oxo-2(1H)-isoquinolinyl)-N-(3-methylbutyl)-, (2E)- | [Molecular Formula]
C20H26N2O4 | [MOL File]
2755772-63-3.mol | [Molecular Weight]
358.43 |
| Chemical Properties | Back Directory | [Boiling point ]
603.3±55.0 °C(Predicted) | [density ]
1.126±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.61±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Immunoproteasome inhibitor 1 is a potent, reversible, time-independent immunoproteasome and proteasome inhibitor (Kis of 1.18, 0.27, 1.91 μM in β5c, β1i, β5i submits, respectively). Immunoproteasome inhibitor 1 can be used for the research of certain neoplastic diseases[1]. | [IC 50]
β5c submit: 1.18 μM (Ki); β1i submit: 0.27 μM (Ki); β2i submit: 20 μM (Ki); β5i submit: 1.91 μM (Ki) | [References]
[1] Ettari R, et al. Development of isoquinolinone derivatives as immunoproteasome inhibitors. Bioorg Med Chem Lett. 2022;55:128478. DOI:10.1016/j.bmcl.2021.128478 |
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