| Identification | Back Directory | [Name]
2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- | [CAS]
2756333-39-6 | [Synonyms]
AZD-9574
2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl- | [Molecular Formula]
C21H22F2N6O2 | [MOL File]
2756333-39-6.mol | [Molecular Weight]
428.44 |
| Chemical Properties | Back Directory | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
8.17±0.20(Predicted) | [color ]
White to yellow | [InChI]
InChI=1S/C21H22F2N6O2/c1-12-20(30)27-18-14(25-12)4-3-13(17(18)22)11-28-7-9-29(10-8-28)16-6-5-15(21(31)24-2)26-19(16)23/h3-6H,7-11H2,1-2H3,(H,24,31)(H,27,30) | [InChIKey]
WXRCLFFPZXJCLS-UHFFFAOYSA-N | [SMILES]
C1(C(NC)=O)=NC(F)=C(N2CCN(CC3C=CC4=C(C=3F)NC(=O)C(C)=N4)CC2)C=C1 |
| Hazard Information | Back Directory | [Uses]
AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD+?breast cancer and advanced solid malignancies research[1]. | [in vivo]
AZD-9574 (3 mg/kg) shows sustained tumour growth suppression resulting in a significantly extended survival of tumour-bearing mice, in intracranial xenograft model of breast cancer brain metastases[1]. | [IC 50]
PPAR | [References]
[1] Hybrid meeting divulges structures of drug candidates
[2] 1.Kunzah Jamal, et al. Abstract 2609: AZD9574 is a novel, brain penetrant PARP-1 selective inhibitor with activity in an orthotopic, intracranial xenograft model with aberrant DNA repair. Cancer Res?(2022) 82 (12_Supplement): 2609. |
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BJBXSW Gold
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18822637905 15801565083 |
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