| Identification | Back Directory | [Name]
Benzamide, N-[2-chloro-6-methyl-4-[[[(1R)-1-(1-methyl-4-piperidinyl)ethyl]amino]sulfonyl]phenyl]-2-methyl- | [CAS]
2756350-98-6 | [Synonyms]
CCR8 antagonist 2
Benzamide, N-[2-chloro-6-methyl-4-[[[(1R)-1-(1-methyl-4-piperidinyl)ethyl]amino]sulfonyl]phenyl]-2-methyl- | [Molecular Formula]
C23H30ClN3O3S | [MOL File]
2756350-98-6.mol | [Molecular Weight]
464.02 |
| Chemical Properties | Back Directory | [density ]
1.249±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
11.11±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220)[1]. | [IC 50]
CCR8 | [References]
[1] Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors. |
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