| Identification | Back Directory | [Name]
AChE/BChE-IN-21 | [CAS]
2756368-79-1 | [Synonyms]
AChE/BChE-IN-21
5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-4-[4-[[5-(1-piperidinyl)pentyl]oxy]phenyl]-, ethyl ester | [Molecular Formula]
C38H54N4O4 | [MOL File]
2756368-79-1.mol | [Molecular Weight]
630.86 |
| Chemical Properties | Back Directory | [Boiling point ]
765.365±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.106±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
11.474±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
AChE/BChE-IN-21 is a histamine H3 receptor antagonist, calcium channel blocker, and acetylcholinesterase inhibitor. AChE/BChE-IN-21 exhibits neuroprotective activity against H2O2 and Aβ1-40, and can restore cognitive function in AD mice[1]. | [References]
[1] Malek R, et al. Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors. ACS Chem Neurosci. 2024 Aug 29. DOI:10.1021/acschemneuro.4c00341 |
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