| Identification | Back Directory | [Name]
Imidazo[1,5-a]pyrimidine, 6-methyl-4-[(3R)-3-methyl-4-morpholinyl]-2-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)- | [CAS]
2756665-52-6 | [Synonyms]
ATR-IN-15
Imidazo[1,5-a]pyrimidine, 6-methyl-4-[(3R)-3-methyl-4-morpholinyl]-2-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-3-yl)- | [Molecular Formula]
C19H22N8O | [MOL File]
2756665-52-6.mol | [Molecular Weight]
378.43 |
| Hazard Information | Back Directory | [Uses]
ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1]. | [IC 50]
ATR: 8 nM (IC50); PI3K: 5131 nM (IC50); ATM: > 10000 nM (IC50) | [References]
[1] Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1. |
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