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Lp-PLA2-IN-14 (Compound 19) is an Lp-PLA2 inhibitor with a pIC50 of 8.4 against rhLp-PLA2. Lp-PLA2-IN-14 can be used for the research of neurodegenerative related diseases, such as Alzheimer Disease (AD), glaucoma, age-related macular degeneration (AMD) or cardiovascular diseases including atherosclerosis and the like[1]. | [IC 50]
rhLp-PLA2: 8.4 (pIC50) | [References]
[1] Zhenghua Gu, et al. Tricyclic pyrimidone compounds, preparation method, composition and application thereof. Patent CN113861220A. |
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