| Identification | Back Directory | [Name]
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 14-(3-fluorophenyl)-8,13,13b,14-tetrahydro- | [CAS]
2757145-67-6 | [Synonyms]
Antitumor agent-53
Indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, 14-(3-fluorophenyl)-8,13,13b,14-tetrahydro- | [Molecular Formula]
C24H18FN3O | [MOL File]
2757145-67-6.mol | [Molecular Weight]
383.42 |
| Hazard Information | Back Directory | [Uses]
Antitumor agent-53 is a potent antitumor agent. Antitumor agent-53 induces cell cycle arrest at the G2/M phase. Antitumor agent-53 inhibits the PI3K/AKT pathway to induce the apoptosis of HGC-27 cells. Antitumor agent-53 has the potential for the research of gastrointestinal tumors[1]. | [References]
[1] Hao X, et al. Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents. Bioorg Med Chem. 2021; 55:116595. DOI:10.1016/j.bmc.2021.116595 |
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