| Identification | Back Directory | [Name]
Benzeneacetamide, N-cyclohexyl-4-methoxy-2-methyl-α-[(4-nitrophenyl)(1-oxo-2-propyn-1-yl)amino]- | [CAS]
2757155-96-5 | [Synonyms]
mIDH1-IN-1
Benzeneacetamide, N-cyclohexyl-4-methoxy-2-methyl-α-[(4-nitrophenyl)(1-oxo-2-propyn-1-yl)amino]- | [Molecular Formula]
C25H27N3O5 | [MOL File]
2757155-96-5.mol | [Molecular Weight]
449.51 |
| Hazard Information | Back Directory | [Uses]
mIDH1-IN-1 (compound 43) is a potent and selective mIDH1 (mutant isocitrate dehydrogenases 1) inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG (2-hydroxyglutarate) production in HT1080 cells, with an EC50 of 208.6 ± 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research[1]. | [References]
[1] Zhou X, et al. Discovery of linear unnatural peptides as potent mutant isocitrate dehydrogenase 1 inhibitors by Ugi reaction. Bioorg Chem. 2022 Feb;119:105569. DOI:10.1016/j.bioorg.2021.105569 |
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