| Identification | Back Directory | [Name]
Benzamide, N-[trans-4-[(3-chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]- | [CAS]
2757422-79-8 | [Synonyms]
N-((1r,4r)-4-((3-chloro-4-cyanophenyl)(methyl)amino)cyclohexyl)-4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)azetidin-3-yl)piperazin-1-yl)benzamide
Benzamide, N-[trans-4-[(3-chloro-4-cyanophenyl)methylamino]cyclohexyl]-4-[4-[1-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-azetidinyl]-1-piperazinyl]- | [Molecular Formula]
C41H43ClN8O5 | [MOL File]
2757422-79-8.mol | [Molecular Weight]
763.3 |
| Chemical Properties | Back Directory | [Boiling point ]
1032.7±65.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
10.83±0.40(Predicted) | [color ]
Light yellow to green yellow |
| Hazard Information | Back Directory | [Uses]
ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1]. | [References]
[1] Weiguo Xiang. et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64(18):13487-13509. DOI:10.1021/acs.jmedchem.1c00900 |
|
|