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Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research[1]. | [in vivo]
Antitumor agent-114 (compound 14c) (2, 0.67, 0.22 mg/kg for intratumoral on day 1, 4, and 7) modulates tumor eradication by systemic immune activation in 4T1 tumor-bearing mice model[1].
| Animal Model: | 4T1 tumor-bearing mice model[1] | | Dosage: | 2, 0.67, 0.22 mg/kg | | Administration: | Intratumoral (i.t.) | | Result: | Reached 80 and 70% tumor growth inhibition (TGI) in the groups treated with 2 and 0.67 mg/kg.
Induced tumor regression in 7 of 8 mice at a dose of 2 mg/kg.
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| [References]
[1] Dejmek M, et al. Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy. Eur J Med Chem. 2023 Nov 5;259:115685. DOI:10.1016/j.ejmech.2023.115685 |
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