| Identification | Back Directory | [Name]
1H-Indole-2,3-dione, 5-[(4-methyl-1-piperazinyl)sulfonyl]-, 3-[2-[4-(4-hydroxyphenyl)-2-thiazolyl]hydrazone] | [CAS]
2757991-65-2 | [Synonyms]
DHFR-IN-1
1H-Indole-2,3-dione, 5-[(4-methyl-1-piperazinyl)sulfonyl]-, 3-[2-[4-(4-hydroxyphenyl)-2-thiazolyl]hydrazone] | [Molecular Formula]
C22H22N6O4S2 | [MOL File]
2757991-65-2.mol | [Molecular Weight]
498.58 |
| Hazard Information | Back Directory | [Uses]
DHFR-IN-1 (compound 12) is a potent and selective DHFR (dihydrofolate reductase)inhibitor, with an IC50 of 40.71 nM. DHFR-IN-1 exhibits promising antibacterial activity against gram-positive and gram-negative bacteria. DHFR-IN-1 exhibits moderate antifungal activities. DHFR-IN-1 exhibits a high synergistic effect with Levofloxacin (HY-B0330), where the FIC (fractional inhibitory concentration index) value is 0.249[1]. | [References]
[1] Alzahrani AY, et al. Development of novel indolin-2-one derivative incorporating thiazole moiety as DHFR and quorum sensing inhibitors: Synthesis, antimicrobial, and antibiofilm activities with molecular modelling study. Bioorg Chem. 2022 Feb;119:105571. DOI:10.1016/j.bioorg.2021.105571 |
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