| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-, hydrochloride (1:2) | [CAS]
2758431-93-3 | [Synonyms]
2-(2,6-dioxopiperidin-3-yl)-5-(4-(piperidin-4-ylmethyl)piperazin-1-yl)isoindoline-1,3-dione dihydrochloride
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-, hydrochloride (1:2) | [Molecular Formula]
C23H30ClN5O4 | [MOL File]
2758431-93-3.mol | [Molecular Weight]
475.97 |
| Hazard Information | Back Directory | [Uses]
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC. | [Biological Activity]
Pomalidomide 5'-piperazine-4-methylpiperidine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand with a terminal piperidine for onward chemistry to generate Protein Degraders with rigid linkers. | [IC 50]
Cereblon | [storage]
Store at -20°C |
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Abosyn
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abosyn.cn/ |
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