| Chemical Properties | Back Directory | [Boiling point ]
634.7±65.0 °C(predicted) | [density ]
1.338±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.49±0.35(predicted) |
| Hazard Information | Back Directory | [Uses]
EGFR-IN-104 (Compound A23) is an effective inhibitor of EGFR, with IC50 values of 0.33 μM and 0.133 μM against EGFRL858R/T790M and EGFRDel19/T790M/C797S, respectively. EGFR-IN-104 exhibits anticancer activity both in vitro and in vivo[1]. | [IC 50]
EGFRL858R/T790M: 0.33 μM (IC50); EGFRL858R/T790M/C797S: 0.133 μM (IC50) | [References]
[1] Xu S, et al. Novel bioactive 2-phenyl-4-aminopyrimidine derivatives as EGFRDel19/T790M/C797S inhibitors for the treatment of non-small cell lung cancer. Arch Pharm (Weinheim). 2024 Feb;357(2):e2300460. DOI:10.1002/ardp.202300460 |
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