| Identification | Back Directory | [Name]
Methanesulfonamide, N-[3-[2-[[4-(1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- | [CAS]
2758999-62-9 | [Synonyms]
FLT3-IN-17
Methanesulfonamide, N-[3-[2-[[4-(1-piperazinyl)phenyl]amino]thieno[3,2-d]pyrimidin-7-yl]phenyl]- | [Molecular Formula]
C23H24N6O2S2 | [MOL File]
2758999-62-9.mol | [Molecular Weight]
480.61 |
| Chemical Properties | Back Directory | [Boiling point ]
756.6±70.0 °C(Predicted) | [density ]
1.415±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
7.85±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
FLT3-IN-17 inhibits CYPs and FLT3 mutants activity (IC50s: <0.5 nM for D835Y). FLT3-IN-17 is also a FAK inhibitor, with an IC50 value of 12 nM. FLT3 ligand-2 can be used in the research of cancers[1]. | [References]
[1] Hanna Cho, et al. Identification of Thieno[3,2- d]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3. J Med Chem. 2021 Aug 26;64(16):11934-11957. DOI:10.1021/acs.jmedchem.1c00459 |
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