| Chemical Properties | Back Directory | [Boiling point ]
694.5±55.0 °C(predicted) | [density ]
1.378±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
11.69±0.43(predicted) |
| Hazard Information | Back Directory | [Uses]
EGFR/ C-Met-in-2 (Compound H-22) is a dual inhibitor of EGFR/c-Met. EGFR/c-Met-IN-2 inhibits cell proliferation by arresting G2/M phase. EGFR/c-Met-IN-2 has antitumor activity[1]. | [References]
[1] Zhang H, et al. Novel quinazoline-based dual EGFR/c-Met inhibitors overcoming drug resistance for the treatment of NSCLC: Design, synthesis and anti-tumor activity. Bioorg Chem. 2024 Jan;142:106938. DOI:10.1016/j.bioorg.2023.106938 |
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