| Identification | Back Directory | [Name]
Benzamide, 5-chloro-N-[6-[(2R)-2,3-dihydroxypropoxy]-4-pyridazinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)- | [CAS]
2761181-58-0 | [Synonyms]
Benzamide, 5-chloro-N-[6-[(2R)-2,3-dihydroxypropoxy]-4-pyridazinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)- | [Molecular Formula]
C22H18ClF4N3O5 | [MOL File]
2761181-58-0.mol | [Molecular Weight]
515.84 |
| Chemical Properties | Back Directory | [Boiling point ]
614.6±55.0 °C(predicted) | [density ]
1.500±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.76±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
Nav1.8-IN-7 (Example 116) is a selective Nav1.8 inhibitor. Nav1.8-IN-7 shows an inhibition of >50% with 100 nM for Nav1.8. Nav1.8-IN-7 inhibits hERG with an IC50 of 15.6 μM. Nav1.8-IN-7 has the potential for pain research[1]. | [in vivo]
Pharmacokinetic Parameters of Nav1.8-IN-7 in male Sprague-Dawley rats[1].
| PO (100 mg/kg) | | Cmax (ng/mL) | 2566 | | AUC0-24 (ng/mL?h) | 42454 | | t1/2 (h) | 8.7 |
| [References]
[1] Junfeng Ren, et al. A benzylamine or benzyl alcohol derivative and its use. CN114031518A. |
|
|