| Identification | Back Directory | [Name]
9H-Purine-2,6-diamine, N6-[4-[(4-aminobutyl)amino]phenyl]-N2-(trans-4-aminocyclohexyl)-9-cyclopentyl- | [CAS]
2761259-22-5 | [Synonyms]
PDGFRα/FLT3-ITD-IN-3
9H-Purine-2,6-diamine, N6-[4-[(4-aminobutyl)amino]phenyl]-N2-(trans-4-aminocyclohexyl)-9-cyclopentyl- | [Molecular Formula]
C26H39N9 | [MOL File]
2761259-22-5.mol | [Molecular Weight]
477.65 |
| Hazard Information | Back Directory | [Uses]
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα/FLT3 with IC50s of 0.153 and 0.004 μM, respectively. PDGFRα/FLT3-ITD-IN-3 has the potential for the research of acute myeloid leukemia or chronic eosinophilic leukemia[1]. | [References]
[1] Vlková K, et al. Synthesis and biological activity evaluation of novel 2,6,9-trisubstituted purine conjugates as potential protein kinases inhibitors. Bioorg Med Chem Lett. 2022 Mar 15;60:128603 DOI:10.1016/j.bmcl.2022.128603 |
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