| Chemical Properties | Back Directory | [Boiling point ]
545.5±50.0 °C(predicted) | [density ]
1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
12.63±0.70(predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1]. | [References]
[1] Yonglei Du, et al. Novel substituted 4-(Arylethynyl)-Pyrrolo[2,3-d]pyrimidines negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGlu5) Treat depressive disorder in mice. Eur J Med Chem. 2023. DOI:10.1016/j.ejmech.2023.115855 |
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