| Chemical Properties | Back Directory | [Boiling point ]
491.664±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.415±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (Warmed) | [form ]
powder | [pka]
9.313±0.50(predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
GLUT4 activator 2 (C59) is an insulin sensitizer, which can be used for research of diabetic diseases. GLUT4 activator 2 improves glucose uptake and insulin sensitivity in rodents. GLUT4 activator 2 interacts with Unc119 and Unc119B resulting in increased insulin sensitivity and GLUT4 translocation[1]. | [Biological Activity]
Orally available potentiator of insulin action th at significantly improves glucose tolerance in DIO mice; restores insulin-stimulated GLUT4 translocation.
| [References]
[1] Yin TC, et al. Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem Biol. 2023 Aug 17;30(8):933-942.e6. DOI:10.1016/j.chembiol.2023.06.012 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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