| Identification | Back Directory | [Name]
4-Phenanthridinamine, 5-ethyl-5,6-dihydro-8,9-dimethoxy- | [CAS]
2761911-40-2 | [Synonyms]
SARS-CoV-2-IN-16
4-Phenanthridinamine, 5-ethyl-5,6-dihydro-8,9-dimethoxy- | [Molecular Formula]
C17H20N2O2 | [MOL File]
2761911-40-2.mol | [Molecular Weight]
284.35 |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-16 (Compound 12) is a potent SARS-CoV-2 nucleocapsid protein (NPro) inhibitor. SARS-CoV-2-IN-16 exhibits potent anti-viral activity with the EC50 of 3.69 μM. SARS-CoV-2-IN-16 binds to NPro with the low KD value of 7.82 μM, suggesting that SARS-CoV-2-IN-16 is a potent NPro ligand[1]. | [References]
[1] Yi-Ting Wang, et al. Novel nucleocapsid protein-targeting phenanthridine inhibitors of SARS-CoV-2. Eur J Med Chem. 2022 Jan 5;227:113966. DOI:10.1016/j.ejmech.2021.113966 |
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