| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole-1-carboxamide, N-[5-(4-methyl-1-piperazinyl)-2-pyridinyl]- | [CAS]
2762279-02-5 | [Synonyms]
ZDLD20
9H-Pyrido[3,4-b]indole-1-carboxamide, N-[5-(4-methyl-1-piperazinyl)-2-pyridinyl]- | [Molecular Formula]
C22H22N6O | [MOL File]
2762279-02-5.mol | [Molecular Weight]
386.45 |
| Chemical Properties | Back Directory | [Boiling point ]
594.5±50.0 °C(Predicted) | [density ]
1.357±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.93±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ZDLD20, a β-carboline, is orally active and selective CDK4/CycD3 inhibitor with an IC50 value of 6.51? μM. ZDLD20 exhibits potent anti-HCT116 activity including inhibition of colony formation, inhibition of invasion and migration, inducing of apoptosis, and arresting of G1 phase in cell cycle. ZDLD20 exhibits potent anticancer activity[1]. | [IC 50]
CDK4/CycD3: 6.51? μM (IC50) | [References]
[1] Deping Li, et al. Facile synthesis of C1-substituted β-carbolines as CDK4 inhibitors for the treatment of cancer. Bioorg Chem. 2022 Apr;121:105659. DOI:10.1016/j.bioorg.2022.105659 |
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