| Identification | Back Directory | [Name]
2-Buten-1-one, 4-[3-[4-[[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]carbonyl]phenoxy]-1-azetidinyl]-1-(1-piperidinyl)-, (2E)- | [CAS]
2762423-09-4 | [Synonyms]
ERα antagonist 1
2-Buten-1-one, 4-[3-[4-[[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]carbonyl]phenoxy]-1-azetidinyl]-1-(1-piperidinyl)-, (2E)- | [Molecular Formula]
C33H32N2O5S | [MOL File]
2762423-09-4.mol | [Molecular Weight]
568.68 |
| Hazard Information | Back Directory | [Uses]
ERα antagonist 1 (Compound 19d) is a potent, selective, covalent estrogen receptor α (ERα) antagonist. ERα antagonist 1 induces apoptosis and cell cycle G0/G1 phase arrest in MCF-7 cells[1]. | [IC 50]
ERα | [References]
[1] Bai C, et al. Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities. Bioorg Med Chem. 2021 Oct 1;47:116395. DOI:10.1016/j.bmc.2021.116395 |
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