| Identification | Back Directory | [Name]
Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]benzoyl]oxy]butyl ester | [CAS]
2763063-09-6 | [Synonyms]
Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, 4-[[4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methoxy]benzoyl]oxy]butyl ester | [Molecular Formula]
C55H70BNO9 | [MOL File]
2763063-09-6.mol | [Molecular Weight]
899.96 |
| Chemical Properties | Back Directory | [Boiling point ]
910.1±65.0 °C(predicted) | [density ]
1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [solubility ]
DMSO: Soluble: = 10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml |
| Hazard Information | Back Directory | [Uses]
Apoptosis inducer 24 (Compound 4) inhibits the proliferation of gastric cancer cells with IC50 of 1.2-4.8 μM. Apoptosis inducer 24 arrests cell cycle at G2/M phase, induces apoptosis in cell BGC-823, and causes mitochondrial dysfunction. Apoptosis inducer 24 exhibits antitumor efficacy in mice, without significant toxicity (LD50 is 91.2 mg/kg)[1]. | [References]
[1] Li N, et al., New CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity. J Med Chem. 2024 Aug 22;67(16):14329-14344. DOI:10.1021/acs.jmedchem.4c01160 |
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