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[Uses]
Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1]. |
[in vivo]
Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1]. | Animal Model: | C57/BL6 mice[1] | | Dosage: | 20 mg/kg | | Administration: | Intragastric administration | | Result: | Exhibited protective effect on LPS-induced ALI in mice. |
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[IC 50]
TNF-α: 2.576 μM (IC50); IL-6: 8.254 μM (IC50) |
[References]
[1] Wang X,et al. Design, synthesis and bioactivity evaluation of fisetin derivatives as potential anti-inflammatory agents against LPS-induced acute lung injury. Bioorg Med Chem. 2021; 49:116456. DOI:10.1016/j.bmc.2021.116456 |