| Identification | Back Directory | [Name]
1-Isoquinolinecarboxamide, 2-(4-chlorobenzoyl)-1,2,3,4-tetrahydro-N-(2-methoxyphenyl)- | [CAS]
2763363-08-0 | [Synonyms]
HSR1304
1-Isoquinolinecarboxamide, 2-(4-chlorobenzoyl)-1,2,3,4-tetrahydro-N-(2-methoxyphenyl)- | [Molecular Formula]
C24H21ClN2O3 | [MOL File]
2763363-08-0.mol | [Molecular Weight]
420.89 |
| Hazard Information | Back Directory | [Uses]
HSR1304 (Compound 5d) is a potent inhibitor of NFκB. The multifunctional transcription factor, nuclear factor-κB (NF-κB), is broadly involved in multiple human diseases, such as cancer and chronic inflammation. HSR1304 has the potential for the research of cancer diseases[1]. | [References]
[1] Sim S, et al. Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway. Bioorg Med Chem. 2021 Sep 15;46:116371. DOI:10.1016/j.bmc.2021.116371 |
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