| Identification | Back Directory | [Name]
Lys-[Des-Arg9]Bradykinin TFA | [CAS]
2763588-90-3 | [Synonyms]
Lys-[Des-Arg9]Bradykinin TFA
Lys-[Des-Arg-9]Bradykinin,TFA,Lys [Des Arg9]Bradykinin,TFA,Lys[DesArg9]Bradykinin,TFA |
| Hazard Information | Back Directory | [Uses]
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors[1][2]. | [in vivo]
Lys-[Des-Arg9]Bradykinin (1 μg; intra-artenal injection; New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T1/2 is 118-195 s)[3]. | [IC 50]
Bradykinin B1 Receptor (B1R) | [References]
[1] Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9. DOI:10.1165/rcmb.2010-0238OC
[2] L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. DOI:10.1124/pr.57.1.2
[3] G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003. PMID:1662280 |
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