| Identification | Back Directory | [Name]
Benzo[b]thiophene-2-carboxamide, N-[2-[2-[[[4-(trifluoromethoxy)phenyl]sulfonyl]amino]ethoxy]ethyl]-, 1,1-dioxide | [CAS]
2764615-55-4 | [Synonyms]
SCP1-IN-1
SCP1 IN 1,SCP1IN1
Benzo[b]thiophene-2-carboxamide, N-[2-[2-[[[4-(trifluoromethoxy)phenyl]sulfonyl]amino]ethoxy]ethyl]-, 1,1-dioxide | [Molecular Formula]
C20H19F3N2O7S2 | [MOL File]
2764615-55-4.mol | [Molecular Weight]
520.5 |
| Hazard Information | Back Directory | [Uses]
SCP1-IN-1 (compound SH T-62) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-1 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-1 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity[1]. | [References]
[1] Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519. DOI:10.1021/acs.jmedchem.1c01655 |
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