| Identification | Back Directory | [Name]
Carbamic acid, N-[[[5-(1H-indol-2-yl)-2-methoxyphenyl]amino]sulfonyl]-, octyl ester | [CAS]
2764818-24-6 | [Synonyms]
Carbamic acid, N-[[[5-(1H-indol-2-yl)-2-methoxyphenyl]amino]sulfonyl]-, octyl ester | [Molecular Formula]
C24H31N3O5S | [MOL File]
2764818-24-6.mol | [Molecular Weight]
473.58 |
| Hazard Information | Back Directory | [Uses]
ALOX15-IN-1 (compound 8b) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 0.04 and 2.06 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1]. | [References]
[1] Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995. DOI:10.1021/acs.jmedchem.1c01563 |
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