| Identification | Back Directory | [Name]
2-Butenoic acid, 4-oxo-4-(4-undecylphenyl)-, (2E)- | [CAS]
2765008-88-4 | [Synonyms]
Atg4B-IN-2
2-Butenoic acid, 4-oxo-4-(4-undecylphenyl)-, (2E)- | [Molecular Formula]
C21H30O3 | [MOL File]
2765008-88-4.mol | [Molecular Weight]
330.46 |
| Chemical Properties | Back Directory | [Boiling point ]
477.7±45.0 °C(Predicted) | [density ]
1.021±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.20±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Atg4B-IN-2 is a potent competitive Atg4B inhibitor with Ki value of 3.1 μM, also possesses declining PLA2 inhibitory potency, IC50s of 11 μM and 3.5 μM for Atg4B and PLA2, respectively. Atg4B-IN-2 enhances the anticancer activity of anti-castration-resistant prostate cancer agents via autophagy inhibition[1]. | [References]
[1] Kudo Y, Endo S, Fujita M, et al. Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer. J Med Chem. 2022;65(6):4878-4892. DOI:10.1021/acs.jmedchem.1c02113 |
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