| Identification | Back Directory | [Name]
Ethanone, 1-[(1S,3R)-6,7-dichloro-1,3,4,5-tetrahydro-1,3-dimethyl-2H-pyrido[4,3-b]indol-2-yl]-2-methoxy- | [CAS]
2765273-11-6 | [Synonyms]
Ethanone, 1-[(1S,3R)-6,7-dichloro-1,3,4,5-tetrahydro-1,3-dimethyl-2H-pyrido[4,3-b]indol-2-yl]-2-methoxy- | [Molecular Formula]
C16H18Cl2N2O2 | [MOL File]
2765273-11-6.mol | [Molecular Weight]
341.23 |
| Chemical Properties | Back Directory | [Boiling point ]
523.6±50.0 °C(predicted) | [density ]
1.323±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
14.69±0.60(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC50 of 0.01512 μM for h-cGAS[1]. | [References]
[1] Ventus Therapeutics U.S., Inc. Pyrido[4,3-b]indole derivatives and their use as pharmaceuticals. World Intellectual Property Organization, WO2022066851 A1 2022-03-31 |
|
|