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2765304-82-1

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2765304-82-1 Structure

2765304-82-1 Structure
IdentificationBack Directory
[Name]

NMS-0963
[CAS]

2765304-82-1
[Synonyms]

NMS-0963
[Molecular Formula]

C23H29N7O3
[MOL File]

2765304-82-1.mol
[Molecular Weight]

451.52
Chemical PropertiesBack Directory
[density ]

1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

13.99±0.46(predicted)
Hazard InformationBack Directory
[Uses]

NMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM[1].
[References]

[1] Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. DOI:10.1016/j.ejmech.2024.116375
2765304-82-1 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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