| Chemical Properties | Back Directory | [density ]
1.651±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml | [form ]
A crystalline solid | [pka]
5.87±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Description]
SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator. | [Uses]
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. | [in vivo]
SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice[1]. | [storage]
Store at -20°C | [References]
[1] Gisele Nishiguchi, et al. Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. J Med Chem. 2021 May 27. DOI:10.1021/acs.jmedchem.0c01313 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
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