| Identification | Back Directory | [Name]
DNA-PK-IN-14 | [CAS]
2766001-96-9 | [Synonyms]
DNA-PK-IN-14
2H-Imidazo[4,5-c]pyridin-2-one, 1,3-dihydro-6-[(4-methoxy-2-methylphenyl)amino]-3-methyl-1-(tetrahydro-2H-pyran-4-yl)- | [Molecular Formula]
C20H24N4O3 | [MOL File]
2766001-96-9.mol | [Molecular Weight]
368.43 |
| Chemical Properties | Back Directory | [Boiling point ]
536.9±50.0 °C(predicted) | [density ]
1.280±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.82±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
DNA-PK-IN-14 (compound 78) is a potent, selective DNA-PK inhibitor with an IC50 value of 7.95 nM. DNA-PK-IN-14 has oral activity and has the potential to be a radiosensitizer for cancer treatment[1]. | [References]
[1] Cho R Hong, et al. Identification of 6-Anilino Imidazo[4,5- c]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers. J Med Chem. 2024 Jul 15. DOI:10.1021/acs.jmedchem.4c01120 |
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