| Identification | Back Directory | [Name]
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride salt | [CAS]
276695-22-8 | [Synonyms]
(Rac)-WAY-161503 (hydrochloride)
8,9-Dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one hydrochloride
8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one hydrochloride salt | [Molecular Formula]
C11H12Cl3N3O | [MDL Number]
MFCD06411596 | [MOL File]
276695-22-8.mol | [Molecular Weight]
308.591 |
| Chemical Properties | Back Directory | [storage temp. ]
room temp | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [color ]
white to off-white | [InChI]
1S/C11H11Cl2N3O.ClH/c12-6-3-8-9(4-7(6)13)16-2-1-14-5-10(16)11(17)15-8;/h3-4,10,14H,1-2,5H2,(H,15,17);1H | [InChIKey]
YPNWSZJDAKOUAW-UHFFFAOYSA-N | [SMILES]
Cl.Clc1cc2NC(=O)C3CNCCN3c2cc1Cl |
| Hazard Information | Back Directory | [Uses]
WAY 161503 Hydrochloride is a potent serotonin 5-HT2C receptor agonist with antiobesity effects. It is the salt analogue of WAY 161503 (D437235). | [Biological Activity]
The 5-HT2C receptors have been implicated in conditions including obesityanxietydepressionOCDschizophreniamigrainenociception and erectile dysfunction. | [in vivo]
(Rac)-WAY-161503 (3-30 mg/kg; i.p.; male C57BL/6J mice) hydrochloride dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082[1].
| Animal Model: | Male C57BL/6J mice with hallucinogen 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)[1] | | Dosage: | 3 mg/kg, 10 mg/kg, 30 mg/kg | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Antagonized the PGE2-mediated inhibition of LPS-induced TNF-α release from rat whole blood culture, in a dose-dependent way. |
| [IC 50]
5-HT2C Receptor: 4 nM (Ki); 5-HT2C Receptor: 12 nM (EC50) | [storage]
Desiccate at RT |
|
| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-58581007 18019463053 |
| Website: |
http://www.coolpharm.com.cn |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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