| Hazard Information | Back Directory | [Uses]
PROTAC AR-V7 degrader-1 (Compound 6) is a potent, orally bioavailable and selective AR-V7 degrader with the DC50 of 0.32 μM by recruiting VHL E3 ligase to Androgen receptor (AR) DNA binding domain (DBD) binder. PROTAC AR-V7 degrader-1 exhibits activity against 22Rv1 cell-line expressing AR-V7 with the EC50 of 0.88 μM[1]. | [IC 50]
VHL | [References]
[1] Archana Bhumireddy,?et al. Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders. Bioorg Med Chem Lett.?2022 Jan 1;55:128448. DOI:10.1016/j.bmcl.2021.128448 |
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