| Identification | Back Directory | [Name]
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide | [CAS]
2768005-77-0 | [Synonyms]
N-[2-Chloro-5-[4-[2-(4-morpholinyl)-5-pyrimidinyl]-6-cinnolinyl]-3-pyridinyl]benzenesulfonamide | [Molecular Formula]
C27H22ClN7O3S | [MOL File]
2768005-77-0.mol | [Molecular Weight]
560.03 |
| Chemical Properties | Back Directory | [Boiling point ]
810.1±75.0 °C(Predicted) | [density ]
1.456±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
6.54±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
PI3K-IN-29 is a potent PI3K inhibitor. PI3K-IN-29 displays good inhibition potencies against U87MG, HeLa and HL60 cells with IC50 values of 0.264, 2.04 and 1.14 μM, respectively. PI3K-IN-29 inhibits PI3K/Akt pathway by inhibiting phosphorylation of Akt that is catalyzed by PI3K[1]. | [References]
[1] Tian C, et al. Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity. Bioorg Med Chem Lett. 2021, 48:128271. DOI:10.1016/j.bmcl.2021.128271 |
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