| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- | [CAS]
2769753-10-6 | [Synonyms]
2,4-Pyrimidinediamine, 5-chloro-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-N2-[4-(1-piperazinyl)phenyl]- | [Molecular Formula]
C23H27ClN6O2S | [MOL File]
2769753-10-6.mol | [Molecular Weight]
487.02 |
| Hazard Information | Back Directory | [Uses]
TAE648 is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). TAE648 can be used for synthesis PROTAC SK-3-91 (HY-137341)[1]. | [References]
[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038
[2] Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288. DOI:10.3892/ijo.2017.3913 |
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