| Identification | Back Directory | [Name]
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- | [CAS]
2769753-42-4 | [Synonyms]
WH-10417-099
4,7,10,13,16-Pentaoxaoctadecanamide, N-[3-[[[4-[6-amino-5-(1,2,3,4-tetrahydro-1-oxo-6-isoquinolinyl)-3-pyridinyl]phenyl]sulfonyl]cyclopropylamino]propyl]-18-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- | [Molecular Formula]
C52H62N8O13S | [MOL File]
2769753-42-4.mol | [Molecular Weight]
1039.16 |
| Hazard Information | Back Directory | [Uses]
WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kγ ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4'-PEG5-acid (HY-131647). | [IC 50]
Cereblon | [References]
[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10. DOI:10.1016/j.cell.2020.10.038 |
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