| Identification | Back Directory | [Name]
2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- | [CAS]
2769954-39-2 | [Synonyms]
BLU-451
2-Propenamide, N-[4-fluoro-3-[[2-[(1-methyl-1H-pyrazol-4-yl)amino]-5-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]amino]phenyl]- | [Molecular Formula]
C24H19F4N7O | [MOL File]
2769954-39-2.mol | [Molecular Weight]
497.45 |
| Hazard Information | Back Directory | [Uses]
Pebezertinib (BLU 451) is an orally active inhibitor for EGFR. Pebezertinib exhibits the ability to penetrate the central nervous system (CNS). Pebezertinib can be used for research about non-small cell lung cancer carrying EGFR exon 20 insertion[1]. | [References]
[1] Zhou Y, et al., Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis. Explor Target Antitumor Ther. 2024;5(3):568-580. DOI:10.37349/etat.2024.00236 |
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| Company Name: |
Shanghai UCHEM Inc.
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| Tel: |
18939844854 |
| Website: |
www.chemicalbook.com/supplier/23967788/ |
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