| Identification | Back Directory | [Name]
CCP peptide | [CAS]
277748-59-1 | [Synonyms]
L-Serine, L-histidyl-L-glutaminyl-L-cysteinyl-L-histidyl-L-glutaminyl-L-α-glutamyl-L-seryl-L-threonyl-N5-(aminocarbonyl)-L-ornithylglycyl-L-arginyl-L-seryl-L-arginylglycyl-L-arginyl-L-cysteinylglycyl-L-arginyl-L-serylglycyl-, cyclic (3→16)-disulfide | [Molecular Formula]
C87H145N41O32S2 | [MOL File]
277748-59-1.mol | [Molecular Weight]
2341.49 |
| Chemical Properties | Back Directory | [density ]
1.70±0.1 g/cm3(Predicted) | [Sequence]
His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16) |
| Hazard Information | Back Directory | [Uses]
CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2]. | [in vivo]
CCP peptide is used as a new antigenic substrate in anti-CCP ELISA to detect anti-citrullinated protein antibodies (ACPAs). The anti-CCP ELISA is extremely specific (98%), with a reasonable sensitivity (68%). The anti-CCP ELISA is very useful for diagnostic and therapeutic strategies in rheumatoid arthritis (RA)[3]. | [References]
[1] Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94. DOI:10.5114/aoms.2011.22067
[2] S?derlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8. DOI:10.1080/03009740310004856
[3] Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63. DOI:10.1002/1529-0131(200001)43:13.0.CO;2-3 |
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