| Identification | Back Directory | [Name]
2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- | [CAS]
2785430-87-5 | [Synonyms]
ALK5-IN-31
2,4-Pyrimidinediamine, N2-[3-fluoro-4-(1-piperazinyl)phenyl]-N4-(8-methyl-4-cinnolinyl)- | [Molecular Formula]
C23H23FN8 | [MOL File]
2785430-87-5.mol | [Molecular Weight]
430.48 |
| Hazard Information | Back Directory | [Uses]
ALK5-IN-31 (compound Ex-08) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-31 has the potential to inhibit growth of tumour in vivo. ALK5-IN-31 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1]. | [References]
[1] Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1. |
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