| Identification | Back Directory | [Name]
4-Ethynyl-L-phenylalanine HCl | [CAS]
278605-15-5 | [Synonyms]
4-Ethynyl-L-phenylalanine
L-Phenylalanine, 4-ethynyl-
4-Ethynyl-L-phenylalanine HCl | [Molecular Formula]
C11H11NO2 | [MDL Number]
MFCD18252809 | [MOL File]
278605-15-5.mol | [Molecular Weight]
189.21 |
| Chemical Properties | Back Directory | [Boiling point ]
343.2±37.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2.22 mg/mL (11.73 mM) | [form ]
Solid | [pka]
2.18±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [in vivo]
p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].
p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].
| Animal Model: | Male Sprague-Dawley rats (200 g)[1] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Decreased in 5-HT and 5-HIAA levels in the rat midbrain. |
| [storage]
Store at -20°C | [References]
[1] Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. DOI:10.1046/j.1471-4159.2000.0742067.x |
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