2787582-17-4

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2787582-17-4 Structure

Chemical Properties	Back Directory
[Boiling point ] 1442.703±65.00 °C(Press: 760.00 Torr)(predicted)
[density ] 1.328±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[pka] 4.161±0.10(predicted)

Hazard Information	Back Directory
[Uses] TP0556351 is a potent and selective matrix metalloproteinase-2 (MMP2) inhibitor with an IC50 value of 0.2 nM. TP0556351 reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model. TP0556351 can be used for researching idiopathic pulmonary fibrosis (IPF)[1].
[in vivo] TP0556351 (0.03, 0.1, 0.3, or 1 mg/kg/day; SC, for 14 days) reduces the amount of collagen in the lungs of a Bleomycin-induced pulmonary fibrosis mouse model^[1].
[IC 50] MMP-2: 0.2 nM (IC₅₀)
[References] [1] Takeuchi T, et al. Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis. J Med Chem. 2022 Jun 23;65(12):8493-8510. DOI:10.1021/acs.jmedchem.2c00613

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