| Identification | Back Directory | [Name]
1H-Pyrrole-3-carboxamide, 1-(3-cyano-5-methyl-2-thienyl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethyl- | [CAS]
2787598-01-8 | [Synonyms]
1H-Pyrrole-3-carboxamide, 1-(3-cyano-5-methyl-2-thienyl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethyl- | [Molecular Formula]
C21H19N5O2S | [MOL File]
2787598-01-8.mol | [Molecular Weight]
405.47 |
| Hazard Information | Back Directory | [Uses]
KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1]. | [References]
[1] Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505 DOI:10.1016/j.bmcl.2023.129505 |
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