| Identification | Back Directory | [Name]
Tolindate | [CAS]
27877-51-6 | [Synonyms]
Dalnate
Methyl(3-methylphenyl)thiocarbamic acid O-(indan-5-yl) ester
Carbamothioic acid, N-methyl-N-(3-methylphenyl)-, O-(2,3-dihydro-1H-inden-5-yl) ester | [Molecular Formula]
C18H19NOS | [MDL Number]
MFCD00865588 | [MOL File]
27877-51-6.mol | [Molecular Weight]
297.41 |
| Hazard Information | Back Directory | [Uses]
Tolindate is a potent PXR agonist with an EC50 value of 8.3 μM. Tolindate shows antifungal activity[1][2]. | [Definition]
ChEBI: Tolindate is a member of indanes. | [References]
[1] Lynch C, et al. Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library. Biochem Pharmacol. 2021 Feb;184:114368. DOI:10.1016/j.bcp.2020.114368
[2] Pastor L, et al. New antifungals selected by molecular topology. Bioorg Med Chem Lett. 1998 Sep 22;8(18):2577-82. DOI:10.1016/s0960-894x(98)00460-0 |
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