| Identification | Back Directory | [Name]
1-(4-Ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-2-propen-1-one | [CAS]
278806-03-4 | [Synonyms]
1-(4-Ethylphenyl)-3-[(6-methyl-1H-benzimidazol-2-yl)thio]-2-propen-1-one | [Molecular Formula]
C19H18N2OS | [MOL File]
278806-03-4.mol | [Molecular Weight]
322.43 |
| Chemical Properties | Back Directory | [Boiling point ]
538.7±60.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
10.52±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
UC-764864 is a UBE2N inhibitor. UC-764864 inhibits UBE2N enzymatic activity. UC-764864 has cytotoxic effects and inhibition of UBE2N-dependent signaling in leukemic cells. UC-764864 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines[1]. | [References]
[1] Barreyro L, et al. Blocking UBE2N abrogates oncogenic immune signaling in acute myeloid leukemia. Sci Transl Med. 2022 Mar 9;14(635):eabb7695. DOI:10.1126/scitranslmed.abb7695 |
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