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2791360-37-5

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2791360-37-5 Structure

2791360-37-5 Structure
IdentificationBack Directory
[Name]

1,1,1-trifluoro-N-(3-(((4-phenylcyclohexyl)oxy)methyl)-1-(pyridin-2-yl)piperidin-4-yl)methanesulfonamide
[CAS]

2791360-37-5
[Synonyms]

OX2R-IN-3
1,1,1-trifluoro-N-(3-(((4-phenylcyclohexyl)oxy)methyl)-1-(pyridin-2-yl)piperidin-4-yl)methanesulfonamide
Methanesulfonamide, 1,1,1-trifluoro-N-[(3R,4S)-3-[[(cis-4-phenylcyclohexyl)oxy]methyl]-1-(2-pyridinyl)-4-piperidinyl]-
[Molecular Formula]

C24H30F3N3O3S
[MOL File]

2791360-37-5.mol
[Molecular Weight]

497.58
Chemical PropertiesBack Directory
[Boiling point ]

581.7±60.0 °C(predicted)
[density ]

1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

5.58±0.40(predicted)
Hazard InformationBack Directory
[Uses]

OX2R-IN-3 (Compound 53) is an orally active type 2 orexin receptor (OX2R) agonist (EC50<100 nM.)[1].
[in vivo]

OX2R-IN-3 (P.O.; 3 mg/kg; single dose) increases mean cortical activation time in SD rats by 105.00 %[1].

[IC 50]

OX2 Receptor: <100 nM (EC50)
[References]

[1] Pennington, Lewis D, et al. Preparation of substituted piperidino compounds and related methods of treatment. United States, US20220194926 A1 2022-06-23
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