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BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7[1]. | [IC 50]
IRAK4: 0.23 nM (IC50) | [References]
[1] Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67(10):8383-8395. DOI:10.1021/acs.jmedchem.4c00560 |
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