28020-36-2

4093-89-4

28020-36-2

GENERAL METHOD: 2-chloro-5-nitropyridine (50 mmol), morpholine (100 mmol), and K2CO3 (100 mmol) were dissolved in THF (50 mL), and the reaction was stirred at 80 °C for 4 hours. Upon completion of the reaction, the mixture was concentrated to 20 mL and subsequently poured into water (100 mL) to precipitate a yellow solid precipitate. After filtration, washing with pure water and drying, the target compound 3a was obtained.Compound 3b was prepared by the same method. Compounds 3a-3b (20 mmol) were mixed with Pd/C (20%, 500 mg) in methanol and subjected to hydrogenation reaction for 12 h at room temperature. At the end of the reaction, the reaction solution was filtered and concentrated to obtain the target compounds 4a-4b.